Burns Regenerative Medicine and Therapy
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Always willing to provide all information, even if it is not what someone wants to hear. No inflation of expectations. Dr Burns and his residents recently performed a reverse shoulder replacement on me. It is difficult to describe how wonderfully pleased I am with the outcome. They did a fabulous job. Regenerative medicine is a field of therapy that harnesses the regenerative properties of certain cells in your own body to help heal diseased or damaged tissues and organs. Regenerative medicine is useful in the treatment of bone, cartilage, tendon, muscle, nerve and soft tissue injuries as well as chronic wounds that were previously thought to be irreparable.
Regenerative medicine-based therapy is increasingly being recommended in the management of various orthopedic conditions due to its diverse benefits listed below. BMA is obtained after processing bone marrow that is removed from your pelvic bone. Xu has developed MEBT — a therapeutic procedure based on the moist environment of the wound, using an ointment that enhances epithelial repair, and in particular that of partial-thickness burns wounds.
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MEBO consists only of natural ingredients including — apart from honey and sesame oil —17 amino acids, 14 fatty acids, and 4 polysaccharides. With this new therapy, which heralds an advancement into a new field of burns medical science, patients sustaining partial-thickness or full-thickness dermis burns cannot only survive what once were life-threatening burns injuries, but can now do so without inordinate pain, immune-depleting surgical excision or the disfiguring scars from the now obsolete surgical technique of skin grafting. Today, the history of burns therapy has advanced into a bright and promising future.
Professor Xu is teaching the world to work with the regenerative forces of nature. In the pages that follow, Professor Xu welcomes collaboration as we surge forward together committed to reducing the pain, disfigurement and suffering of burns patients the world over. Let us strive together for this noble and finally attainable goal. On the occasion of the publishing of Burns Regenerative Medicine and Therapy, I would like to share with readers the insights into the genesis, current research status and exciting advances in this critically important realm of health sciences — regenerative medicine.
Consideration of Scientific Paradigms and Research Reasoning from the Viewpoint of Foundation and Development of Medical Science Systems Medical historians today are fortunate to be able to scan, across thousands of years, the extensive research focusing on human health problems and related therapies which have evolved today into the modern disciplines of life science and medicine. As early as 2, years ago, both eastern and western medicine originally arose from an apprenticeship with nature and natural phenomena.
This documentation represents the development of medicine away from sorcery and en route to being used as the foundation of Chinese medicine. Hua Tuo — AD was the most famous doctor in ancient China who developed the use of Mafei San surgical anesthesia a good 1,—1, years before western doctors learned about ether and other chemical or pharmacological anesthetic agents. Ancient Greece and Rome dominated the empiricism of the ancient west. With about 2, years of development, there came into being two academic systems: eastern and western medicine.
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Eastern medicine, 5 which originated from ancient Chinese medicine, has brought tons of benefits and contributions to human health by providing treatments based on plain philosophy and holism, while western medicine experienced two periods: one during the warring period of ancient Egypt and ancient Rome when the massive wounded were treated, which brought morphologic research from anatomy to applied surgery, and the other during the Renaissance when medicinal chemistry was developed based on alchemy, thereby resulting in the rudiments of modern western medicine and surgery.
Historically, both eastern and western medicine have continuously integrated modern scientific discoveries into their medical treatments and thus continued to develop. However, historians might also question what kind of significant benefits, whether in Chinese or western medicine, these discoveries have played in promoting human health and in effectively treating diseases.
Let me share with you an image that concerns me. Imagine a modern, well-educated medical doctor holding a knife in his left hand and a pharmaceutical drug, a cellular poison, in his right. Is that OK? And because no one offered a more reasonable option, western drugs today are made primarily of chemical toxins which are incompatible with life and which, not surprisingly, when applied to diseased human beings, inevitably have deleterious side effects on health.
Therefore, it is not an unjust comparison to liken western drugs to poison when seen in the context of the rule of life or vitality. For many centuries, medical professionals the world over have sought to reduce drug toxicity as much as possible while many governments have set up national drugcontrol administrations to ensure drug safety for humans. Where is the new medical system that conforms to the principles of human vitality? In which direction should the practice of human medicine go? Herein, I would like to share with devoted readers the exciting story of the establishment of regenerative medicine and therapy as well as our compelling research which supports this new paradigm shift towards a medicine which is in accordance with the laws of human health and wellness.
We inaugurated the research into the secrets of regenerative medicine and therapy in early Although many difficult challenges fell before us since the year we established out Research Center , our published research results demonstrate that we are presently 6 Burns Regenerative Medicine and Therapy amongst the leaders in this field.
Back in , I published research demonstrating the heretofore unthinkable result of scar-free healing of burns through the application of regenerative cells. The clinical results were impressive and the pictures demonstrating irrefutable clinical effects no scars are available for the interested reader in The Chinese Journal of Burns, Wounds and Surface Ulcers.
Subsequently, the work done by Dr. James A. Thomson and his colleagues from Wisconsin University in revealed that when cells were isolated directly from the inner cell mass of human embryos at the blastocyst stage and then cultured in vitro to produce a pluripotent stem cell line, they would then transform into many types of cells. Meanwhile, Dr.
John Gearhart and his colleagues isolated pluripotent stem cells from fetal tissue of terminated pregnancies and confirmed Dr. This technological achievement triggered a burst of stem cell research and a whirlwind of ethical debate followed immediately by a drive for commercialization, some of which was quite unscrupulous. For example, a certain laboratory announced that they had created a human ear on the dorsum of rats.
More stir! Not surprisingly though, on closer inspection, we learned that their statement was not actually true. In fact, the scientists in that laboratory did something different though not entirely insignificant. They managed to first make a human ear model scaffold using polyglycolic acid macromolecule chemical material and then, after placing this structure beneath the rat subcutis, cartilage cells cultured and proliferated within the said scaffold creating something that looked like an ear but was not one at all. Like a shadow perpetually attached to its master, commercialization is never far from the frontiers of science.
Imagination, while an important component of science, is only a distraction unless the rigor of the scientific method is also employed. No trickery is allowed. Unfortunately, such tricky performances — such as human ears on the backs of mice — disturb the current field of stem cell research. Traditionally, Chinese scientists and doctors prefer to investigate principles from experimental results and holistic concepts in order to discover tri-dimensional development modes en route to comprehensive conclusions.
In contrast, westerners are adept at imaging from scantling phenomenon, then designing several research directions for further exploration before finally attaining an answer. The Western mode of research necessarily requires adequate funding which seems to not be in short supply. For example, a result that might require ten thou- sand dollars in China might require, in the West, a price of ten million dollars. Nonetheless, despite funding discrepancies, we are pleased to reveal that, though relatively underfunded, Chinese researchers have accomplished the clinical application of regenerative medicine while Western researchers are still formulating strategies.
This difference in degree of clinical success validates the eastern way of thinking about research, which produces empirically superior clinical results in an expeditious manner. Our focus in this book will be to reveal that the clinical results springing from the research on burns wherein data suggest that most dry wounds heal with scar formation whereas most moist wounds heal with less scarring. While probing the mechanism of this superior healing over many years, we discovered one type of unknown cell that has a regenerative capacity which may play a significant role in this process.
After years of basic research and clinical study, we found that the cells with regenerative potential turned out to be keratin 19 positive expressed epidermis stem cells which appear to be the primitive cells at the start of human embryonal development. Coincidently, this understanding shed a great light on the mystery of optimal physiological healing of deep burns by regeneration. Using wound repair as a model, we dynamically demonstrated that the process of skin regeneration and development can resemble embryonic tissue development.
Based on the discovered skin regenerative law, we conducted experimental studies on the regeneration and repair of tissues and organs of mammals by creating a vital environment.
I am now pleased to report that up to the present, we have had consistent success in repairing and regenerating 55 types of tissues and organs. Healing with scar formation is the result of aberrant and suboptimal physiological processes while scarfree healing is the result of healthy and appropriate physiological processes working in conjunction with the forces of regeneration.
Mankind has always known this to be true but until now has failed to discover the dynamics behind the variable healing results. Certainly, if one could comprehend and reveal this mystery in order to apply it to medical fields, then the health of people the world over would be astonishingly enhanced.
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Such a goal is worthy and, accordingly, that has been my focus and aspiration since I pioneered the science of regenerative medicine and therapy many years ago. In fact, each tissue or organ, including epidermis, epithelium mucosa, vascular endotheliocyte as well as blood cell in human body is engaged in exactly this process all the time. Disease, therefore, can be understood to occur when the speed of repair is slower than the speed of injury. Until the present, a lot of pathological and physiological mechanisms remain obscure to those using the conventional paradigm.
Therefore, in order to uncover the mystery of regeneration in human body, we must avoid the thoughts of traditional medical thought and instead utilize a new body of thought which we can apply to the observation and study of human physiology. This new body of science has led us to the field of regenerative medicine.